The Molecular Screening and Therapeutics (MoST) clinical trials personalise experimental treatments based on an individual’s unique cancer genetic profile. Because of this, eligibility for participation is independent of where the cancer arises in the body. In these trials, rather than focusing on a tumour’s location, such as the ovaries or pancreas, patients who have a shared harmful genetic variant, are treated with a drug that may target the variant, even if they have different types of cancer.
Clinical trials are generally used to test a new treatment, with some patients getting the new drug and the others getting an existing drug or a placebo. One-third of GCMP patients will have a biomarker matched to a targeted therapy, while those remaining may be directed on to other trials or therapies, including immunotherapies.
More information can be found here - https://www.garvan.org.au/research/collaboration/genomic-cancer-medicine-program